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Hyperkalemia panguva yerenin-angiotensin-aldosterone system inhibition (RAAS-I) inogona kudzivirira optimum dosing.Nzira dzekurapa dzinosanganisira sodium polystyrene sulfonate potassium binding resins, asi kuchengetedzeka uye kushanda zvakanaka kuripo, kusanganisira inobatanidzwa colonic necrosis (CN).Mimwe mishonga yakadzidzwa, asi mutengo-utility hauna kufungidzirwa. Takaita ongororo yemutengo-utility yevarwere vari kunze ≥ makore 18 ezera vachiwana chisingaperi RAAS-I, ine nhoroondo ye hyperkalemia kana chirwere cheitsvo chisingaperi, chakapihwa sodium polystyrene sulfonate. kana kuti theoretical "drug X" inosunga resin yekusingaperi hyperkalemia.Mashoko akawanikwa kubva mumabhuku aripo.Takashandisa sarudzo yekuongorora modhi neMonte Carlo probabilistic sensitivity analysis, kubva pakuona kwevanobhadhara hutano uye nemwedzi gumi nemaviri.Mari yakayerwa nemadhora ekuAmerica.Kubudirira kwakayerwa muhutano-yakagadziriswa makore ehupenyu (QALYs), uye kuwedzera kwemari-effectiveness ratios (ICERs) .Mushonga X waigona kudhura zvisingasviki $ 10.77 pamutengo wezuva nezuva kuti ushande, pakuda-kubhadhara ( WTP) chikumbaridzo che $ 50,000/QALY.Pamadhora makumi mana pamadhora makumi mana pazuva, mushonga X wakawana chiyero chekuwedzera kwemutengo we $26,088,369.00 paQALY yakawanikwa.One-way sensitivity analysis yakaratidza sodium polystyrene sulfonate kuti ive iyo inodhura-inoshanda sarudzo yeCN incidences ≤ 19.9%.Kukanganisa kunosanganisira ruzivo rusina kukwana pamusoro pemigumisiro yechirwere chekunze uye kushayikwa kwemashoko zvakananga kuenzanisa sodium polystyrene sulfonate kune zvingave zvingasarudzwa.Zvimwe zvingasave zvisingadhuri kunze kwekunge mutengo wakafanana kune sodium polystyrene sulfonate.Ongororo iyi inogona kutungamira sarudzo maererano nekugamuchirwa kwemamwe maajenti echisingaperi hyperkalemia control, uye inoratidza kuti sodium polystyrene sulfonate ishandiswe seyakashinga kutonga mune yekiriniki miedzo yeava vamiririri.