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ATP-gated P2X3 receptors inokosha transducers ye nociceptive stimuli uye inenge yakanyatsoratidzwa ne sensory ganglion neurons.Mumouse trigeminal ganglion (TG), P2X3 receptor basa rinowedzerwa zvisingatarisirwi ne pharmacological block ye natriuretic peptide receptor-A (NPR-A), inotsanangura inogona inhibitory basa re endogenous natriuretic peptides mu nociception inopindirana neP2X3 receptors.Kushaikwa kweshanduko muP2X3 mapuroteni kutaura kunoratidza kurongeka kwakaoma kune nzira dzekudzikisa P2X3 receptor basa rinoramba risingazivikanwe. blocker anantin.Nekudaro, isu takaongorora shanduko muP2X3 receptor kugovera muiyo lipid raft membrane compartment, yavo phosphorylation state, pamwe nebasa ravo nechigamba clamping.Kunonoka kutanga kweP2X3 desensitization yaive imwe nzira yeanantin-induced kusimudzira kweP2X3 chiitiko.Anant mukushandisa yakakonzera kudiwa kweP2X3 receptor kugovera kune iyo lipid raft compartment uye kuderera kweP2X3 serine phosphorylation, zviitiko zviviri zvakanga zvisingapindirani.An inhibitor yeCGMP-inotsamira protein kinase uye siRNA-mediated knockdown yeBNP yakatevedzera mabatiro eanantin.Takaratidza kuti mu mouse trigeminal neurons endogenous BNP inoshanda paNPR-A receptors kuona zvinoumba kushushikana kweP2X3 receptor basa.Tonic inhibition yeP2X3 receptor basa neBNP/NPR-A/PKG nzira inoitika nenzira mbiri dzakasiyana: P2X3 serine phosphorylation uye receptor redistribution kune asiri-raft membrane membrane compartments.Iyi itsva nzira yekugamuchira kutonga inogona kunge iri chinangwa chezvidzidzo zvenguva yemberi zvine chinangwa chekudzikisa dysregulated P2X3 receptor basa mukurwadziwa kusingaperi.