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Kuongorora mhedzisiro yemafuta emushonga pane emphysema-se shanduko uye kutaura kwe tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) uye tishu inhibitor ye metalloproteinase. -1 (TIMP-9) mu lipopolysaccharide (LPS) yakabatwa makonzo.Emphysematous shanduko yemuenzaniso yakakonzerwa ne intracheal instillation yeLPS kamwe chete pavhiki kusvika kumavhiki masere mumakonzo.Makonzo akakamurwa kuita kudzora, dexamethasone (0.3 mg x kg (-1)), uye spearmint mafuta (10, 30,100 mg x kg (-1)) mapoka.Boka rega rega rairapwa nesaline, dexamethasone, uye spearmint yemafuta zvakateerana kwemavhiki mana.Ipapo huwandu uye hwakasiyana hwemasero machena eropa mubronchoalveolar lavage fluid (BALF) yakaitwa.Iko kushanduka kwepathologic yemapapu matishu akadai sealveolar chimiro, kuzvimba kwemhepo, uye goblet cell metaplasia yakaonekwa neHE uye AB-PAS kusvibiswa.Kutaura kweTNF-alpha, IL-1beta, TIMP-1 uye MMP-9 kwakayerwa.Zvose spearmint uye dexamethasone zvakaderedza kuparadzwa kwepulmonary alveolus.Zvose uye zvakasiyana-siyana zvemasero machena eropa muBALF kusanganisira neutrophile uye lymphocyte ye spearmint mafuta 100 mg x kg (-1) uye boka re dexamethasone rakaderedzwa zvakanyanya, uye goblet cell metaplasia yakadziviswawo.Dexamethasone yakanga ine inhibitory effect pakutaura kweTNF-alpha, IL-1beta, TIMP-1 uye MMP-9.Spearmint mafuta 30, 100 mg x kg (-1) zvakanyanya kuderedza TNF-alpha uye IL-1beta maererano.Spearmint mafuta 10, 30 uye 100 mg x kg (-1) yakanga isina simba pakutaura kweTIMP-1, asi inogona kuderedza kutaura kweMMP-9 zvakanyanya mumapapu emapapu. sezvo inovandudza kuparadzwa kwealveolar, kuzvimba kwepulmonary, uye goblet cell metaplasia.Iyo michina inogona kusanganisira kuderedza TNF-alpha, IL-1beta yemukati uye inhibiting overexpression yematrix metalloproteinase-9 mumapapu tishu.