Adenosine 5'-monophosphate disodium munyu Cas:4578-31-8
| Catalog Number | XD90587 |
| Product Name | Adenosine 5'-monophosphate disodium munyu |
| CAS | 4578-31-8 |
| Molecular Formula | C10H12N5Na2O7P |
| Molecular Weight | 391.18 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | Upfu huchena kana husina kuchena |
| Assay | 99% |
| Heavy metals | <10ppm |
| Storage Temperature | +20 ° C |
| Mvura Yemukati | <26.0% |
Kuongorora kwe pharmacodynamics mukuwedzera kune pharmacokinetics ndeimwe yemaitiro ega ega mycophenolate mofetil therapy.Chinangwa chechidzidzo ichi chaive chekugadzira hunyanzvi hwechimvuramabwe chromatography-tandem mass spectrometry (LC-MS/MS) nzira dzekuongorora pharmacokinetics uye pharmacodynamics yemycophenolic acid (MPA).Concentrations ye mycophenolic acid glucuronide (MPAG), mycophenolic acid acyl-glucuronide, pamwe neMPA isina kuvharwa neMPAG, yakatemwa, uye inosine-5'-monophosphate dehydrogenase chiitiko chakaverengerwa nekuyera huwandu hweyakagadzirwa xanthosine-5'-monophosphate (XMP). ) uye intracellular adenosine-5'-monophosphate mushure mekuiswa kweperipheral blood mononuclear cell (PBMC) lysates.Iyo simbi-isina Mastro(TM) column uye maviri gradient mapatani akashandiswa kuvandudza huwandu hwehuwandu hweXMP kusvika 0.1 μM.Mukiriniki yeMPA yekumisikidzwa, mutsara weiyo calibration curve, pakati- uye mukati-yemazuva nemazvo uye huchokwadi hwakagutsa revs reUS Food and Drug Administration nhungamiro.Iyo MPA yekutarisa mu hematopoietic stem cell transplant (HSCT) varwere vakagadziriswa ne enzyme assay uye ikozvino LC-MS / MS nzira yakaratidza kuwirirana kwakanaka (r (2) = 0.95, p <0.001).Muchidzidzo ichi, tinoshuma nzira dzakasimba uye dzakasimbiswa dzeLC-MS/MS kuti tiongorore pharmacokinetics uye pharmacodynamics yeMPA, iyo inonzwisisika zvakakwana kuongorora zviduku zvePBMC lysates zvakaunganidzwa nguva pfupi mushure meHSCT.
