Cytidine Cas: 65-46-3 White crystalline poda 99%
| Catalog Number | XD90586 |
| Product Name | Cytidine |
| CAS | 65-46-3 |
| Molecular Formula | C9H13N3O5 |
| Molecular Weight | 243.22 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | White crystalline powder |
| Assay | 99% |
| Heavy metals | <20ppm |
| Chemical Formula | C9H13N3O5 |
| Kurasika paKuomesa | <0.5 % |
| Residue paIgnition | <0.10 % |
Kuwanikwa kweserura kwe deoxynucleoside triphosphates (dNTPs) kwakakosha pakudzokorora nekugadzirisa DNA.Muchidzidzo ichi, takaongorora basa reCMP/UMP kinase (CMPK), enzyme inokonzeresa kuumbwa kweCDP, mukugadzirisa kweDNA.Knockdown yeCMPK inononoka kugadzirisa DNA panguva yekupora kubva kuUV kukuvara mumaseru-akanyimwa maseru asi kwete mumaseru asina kushaikwa kweserum.Exogenous supply ye cytidine kana deoxycytidine inobatsira DNA kugadziriswa kunoenderana neCMPK mumaseru-akanyimwa maseru, zvichiratidza kuti synthesis yedCDP kana CDP inotarisa chiyero chekugadzirisa.Nekudaro, kugogodza kweCMPK hakukanganise danho rakatsiga reiyo dCTP mumaseru-akanyimwa maseru.Takazowana kugariswa kweCMPK panzvimbo dzekukuvara kweDNA uye kuumbwa kwayo kwakaoma neTip60 uye ribonucleotide reductase.Ongororo yedu yakaratidza kuti N-terminal 32-amino-asidhi yeCMPK inodiwa pakutsvaga kwayo kunzvimbo dzekukuvadzwa kweDNA nenzira inotsamira paTip60.Tsanangudzo yemhando yemusango asi isiri N-terminus yakadzimwa CMPK inodzoreredza kushanda kweDNA kugadzirisa muCMPK knockdown maseru.Isu takakurudzira kuti saiti-chaiyo dCDP kuumbwa kuburikidza neCMPK inopa nzira yekufambisa kugadzirisa DNA mumaseru-akanyimwa maseru.
