Citicoline sodium Cas:33818-15-4 CYTIDINE-5′-DIPHOSPHOCHOLINE
| Catalog Number | XD90590 |
| Product Name | Citicoline sodium |
| CAS | 33818-15-4 |
| Molecular Formula | C14H25N4NaO11P2 |
| Molecular Weight | 510.31 |
| Storage Details | -20°C |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | White Solid |
| Assay | 99% |
| Melting point | 250°C(Dec.)(lit.) |
| Boiling point | °Katsi 760mmHg |
| PSA | 238.17000 |
| logP | -0.14090 |
| Solubility | H2O: 100mg/mL |
Citicoline (CDP-choline) murevereri akakosha mu biosynthesis ye phosphatidylcholine, chikamu chakakosha cheneural cell membrane.Yakaratidzwa kuburitsa mhedzisiro inobatsira mune ese emhando yemhuka uye isiri-US yekiriniki sitiroko miedzo.Ichi chidzidzo chaisanganisira randomized (3 doses of citicoline to 1 placebo), motokari-inodzorwa, kaviri-mapofu muedzo pa21 US nzvimbo.Kurapa kwaifanira kutangwa mukati memaawa makumi maviri nemana ekurohwa kwesitiroko uye kwakaenderera mberi nemuromo kwemavhiki matanhatu.Mhedzisiro yemhedzisiro yekuongororwa yaive pamavhiki e12.Varwere mazana maviri nemakumi mashanu nevapfumbamwe vakanyoreswa, uye vangangoita 65 mune rimwe nerimwe remapoka mana.Nguva yakareba kubva pakurohwa kusvika pakurapwa kwaiva maawa 14.5, uye pakanga pasina misiyano inokosha muhutano hwepakutanga pakati pemapoka mana kunze kwekuremerwa kwevarwere.Musiyano wakakura pakati pemapoka, kufarira kurapwa kwe citicoline, wakaonekwa maererano nemhedzisiro yekushanda sekuyerwa neBarthel Index uye Rankin scale, neurologic evaluation yakayerwa neNational Institutes of Health (NIH) sitiroko scale, uye cognitive basa sezvakayerwa ne iyo Mini Mental Status Examination.Apo nheyo yekutanga yeNIH stroke scale yakashandiswa se covariate, zvose 500-mg citicoline boka uye 2,000-mg citicoline boka rakava nekuvandudzwa kukuru maererano nezana revarwere vaiva nemigumisiro yakanaka paBarthel Index pamazuva 90.Pakanga pasina zviitiko zvakakomba zvine chekuita nezvinodhaka kana kufa muongororo iyi.Ichi chidzidzo chinoratidza kuti oral citicoline inogona kushandiswa zvakachengeteka ine mishoma mhedzisiro muacute sitiroko kurapwa.Citicoline inoratidzika kuvandudza kushanda kwemaitiro uye kuderedza neurologic deficit ne 500 mg ye citicoline inoratidzika seyo yakakwana dose.
