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Kurapa kwemasero emammalian ane chemotherapeutic zvinodhaka zvinogona kukonzera kukanganisa kwemadziva enucleotide.Kutarisa izvi zvinokanganisa mumaseru ebundu akagadzirwa kubva kuvanhu kunobatsira pakuongorora mashandiro ekurapa zvinodhaka uye kunzwisisa kuri nani kwemaitiro ekuita kwemishonga iyi.Muchidzidzo ichi, makirasi matatu emishonga yemakemikari ane nzira dzakasiyana dzekuita akashandiswa mukugadzirwa kwemasero akabatwa nemishonga.Iyo LC-yakavakirwa metabolomics kuongororwa kweiyo nucleotides mumasero eboka rekutonga uye boka rakabatwa nemishonga rakaitwa.Nzira dzinoverengeka dzekugadzirisa data dzakabatanidzwa pakuzivikanwa kweanogona biomarkers ane chekuita nekuita kwemishonga, kusanganisira imwe-nzira yekuongorora yekusiyana, principal component analysis, uye receiver operating characteristic curves.Zvinoshamisa, masero emamota eboka rinodzora uye mapoka akabatwa nemishonga anogona kusiyaniswa kubva kune mumwe nemumwe, uye akati wandei akazivikanwa se potentia l biomarkers, senge ATP, GMP, uye UDP kune antimetabolite agents, ATP, GMP, uye CTP. yeDNA-inokuvadza vamiririri, pamwe neGMP, ATP, UDP, uye GDP kune mitotic spindle agents.Kumwe kusimbiswa kweanogona biomarkers kwakaitwa pachishandiswa inogamuchira inoshanda hunhu curve.Tichifunga nezvenzvimbo yavo inowirirana pasi pe curve, iyo yaive yakakura kupfuura 0.9, zvinogona kugumiswa kuti GMP neATP ndiyo yakanakisa inogona biomarkers yeDNA-inokuvadza mishonga, pamwe neGMP, ATP, uye UDP kune mamwe makirasi maviri emishonga.Iyi nzira shoma ye nucleotide haigoni kusiyanisa zvachose nzira dzemishonga mipfumbamwe, asi inopa humbowo hwekutanga hwebasa re pharmacemetabolomics mukugadzirwa kwepreclinical yemishonga zvishoma.