D-Leucine Cas: 328-38-1 99% White powder
| Catalog Number | XD90305 |
| Product Name | D-Leucine |
| CAS | 328-38-1 |
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.17292 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29224985 |
Chigadzirwa Specification
| Kutenderera chaiko | -14 kusvika -16 |
| AS | <1ppm |
| Pb | <10ppm |
| Kurasika paKuomesa | <0.20% |
| Assay | 99% |
| Residue paIgnition | <0.10% |
| Cl | <0.020% |
| Chitarisiko | Upfu chena |
Zvinhu zvakatipoteredza, senge macronutrient kuumbwa kwechikafu, zvinogona kukanganisa zvakanyanya panjodzi yechirwere cheshuga uye metabolic syndrome.Muchidzidzo chezvino tinoratidza kuti imwe chete, yakapfava yekudya chinhu--leucine---inogona kushandura insulin kuramba nekuita pane akawanda matishu uye pamazinga akawanda emetabolism.Mbeva dzakaiswa pane zvakajairwa kana zvakakwirira mafuta kudya (HFD).Dietary leucine yakapetwa kaviri nekuwedzera kumvura yekunwa.mRNA, mapuroteni uye akazara metabolomic profiles akaongororwa mune makuru insulin anonzwa tishu uye serum, uye yakabatana nekuchinja kweglucose homeostasis uye insulin kusaina.Mushure memavhiki e8 paHFD, mbeva dzakagadzira kufutisa, chiropa chemafuta, kuchinja kwechirwere mu adipose tissue uye insulin kudzivisa pamwero we IRS-1 phosphorylation, pamwe nekushandurwa kwemetabolomic profile yeamino acid metabolites, TCA cycle intermediates, glucose uye cholesterol metabolites. , uye mafuta acids muchiropa, tsandanyama, mafuta uye serum.Kupeta kaviri kwekudya leucine reve rsed akawanda eiyo metabolite abnormalities uye yakakonzera kuvandudzwa kweglucose kushivirira uye kusaina insulin pasina kushandura kudya kwekudya kana kuwanda.Kuwedzera kwekudya leucine kwakabatanidzwawo nekuderera kwehepatic steatosis uye kuderera kwekuzvimba mune adipose tishu.Kuchinja uku kwakaitika pasinei nekuwedzera kwe insulin-inosimudzira phosphorylation yep70S6 kinase ichiratidza kushandiswa kweMTOR, chiitiko chinowanzobatanidzwa ne insulin resistance.Aya data anoratidza kuti shanduko ine mwero mune imwechete yezvakatipoteredza / inovaka muviri inogona kushandura akawanda metabolic uye masaini nzira uye kugadzirisa HFD induced metabolic syndrome nekuita padanho rehurongwa pamatishu akawanda.Aya data zvakare anoratidza kuti kuwedzera kwekudya leucine kunogona kupa adjunct mukutarisira kufutisa-kwakabatana ne insulin kuramba.
