Muhupo hwe 2.8 mM D-glucose, beta-D-glucose pentaacetate (1. 7 mM) yakawedzera insulin kusunungurwa kubva kune yakaparadzaniswa rat pancreatic islets kupfuura alpha-D-glucose pentaacetate.Saizvozvovo, kuwedzera kwekuwedzera kwekubuda kwe insulin kwakaburitswa nenateglinide (0.01 mM) yaive yakakwira muzvitsuwa zvakafumurwa kune beta- pane alpha-D-glucose pentaacetate.Mukati, pamberi pe2.8 mM isina kusimbiswa D-glucose, alpha-L-glucose pentaacetate, asi kwete beta-L-glucose pentaacetate, zvakanyanya kuwedzera insulin kubuda.Iyo yakakwira insulinotropic potency ye beta-anomer yeD-glucose pentaacetate yakabatana nekuti yakawedzera zvakanyanya paired ratio pakati peD- [U-14C]glucose oxidation uye D- [5-3H] kushandiswa kweglucose, nepo alpha-D. -glucose pentaacetate yakakundikana kuita kudaro.Izvi zvakawanikwa zvinodudzirwa kutsigira pfungwa yekuti kukurudzirwa kwe insulin kusunungurwa nema esters aya kunonyanya kukonzerwa nekubatana kwavo kwakananga ne stereospecific receptor, nekuda kwekugadziriswa kweC1 inowanzoita beta-D-glucose pentaacetate uye alpha-L- glucose pentaacetate.
