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RasGrf1 uye RasGrf2 ane homologous mammalian guanine nucleotide kuchinjanisa zvinhu izvo zvinokwanisa kumisa chaiyo Ras kana Rho GTPases.Iwo maRasGrf majini anonyanya kuratidzwa mukati mepakati tsinga system, kunyangwe kutaura chaiko kweimwe locus kunogona kuitika kumwewo.RasGrf1 igeni rinotaurwa nababa, rakadhindwa rinoratidzwa mushure mekuzvarwa chete.Mukupesana, RasGrf2 haina kudhindwa uye inoratidza yakafara nzira yekutaura.Yakasiyana-siyana isoforms yemajini ese ari maviri anoonekwa zvakare mune akasiyana cellular mamiriro.Mapuroteni eRasGrf anoratidza modular zvimiro zvinoumbwa neakawanda madomasi anosanganisira CDC25H uye DHPH motifs ane basa rekusimudzira GDP/GTP kuchinjanisa, zvichiteerana, paRas kana Rho GTPase zvinangwa.Iwo akasiyana madomasi akakosha kutsanangura yavo yemukati yekutsinhanisa chiitiko uye kugadzirisa iyo chaiyo yebasa ravo rekuita kuitira kuti abatanidze akasiyana masaini ekukwira kune akasiyana-siyana ekudzika kwakadzika uye mhinduro dzenhare.Zvisinei nehomology yavo, RasGrf1 neRasGrf2 vanoratidza zvakasiyana siyana zvakanangwa uye zvisingapindirane mabasa ekuita mune akasiyana masigning mamiriro ane chekuita nekukura kwesero uye kusiyanisa pamwe nekunakidzwa neuronal uye mhinduro kana synaptic plasticity.Kunyange zvazvo maRasGrfs maviri ari kushandiswa ne glutamate receptors, G-protein-coupled receptors kana kuchinja mu intracellular calcium concentration, RasGrf1 chete inonzi inoshandiswa neLPA, cAMP, kana agonist-activated Trk uye cannabinoid receptors.Ongororo yemhando dzakasiyana dzembeva dzekugogodza dzakafumura mupiro chaiwo weRasGrf1 mumaitiro ekurangarira nekudzidza, kutora mifananidzo, kutonga kwekukura kwepashure uye kukura kwemuviri uye pancreatic β-cell basa uye glucose homeostasis.Kune RasGrf2, mabasa chaiwo mukuwedzera kwe lymphocyte, T-cell kusaina mhinduro uye lymphomagenesis yakatsanangurwa.