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BBS4 ndeimwe yemapuroteni akati wandei ane hurema hunokonzera Bardet-Biedl syndrome (BBS), chirwere chemulti-systemic, chinoratidza kufutisa.BBS4 polymorphisms yakabatanidzwa neyakajairwa isiri-syndromic morbid kufutisa.BBS4 kufutisa mamorekuru maitiro, uye basa reiyo BBS4 gene mukusiyanisa adipocyte uye basa hazvizivikanwe zvachose.Isu zvino tinoratidza kuti Bbs4 inobata basa rakananga uye rakakosha mukupararira uye adipogenesis: kunyarara kweBbs4 mu3T3F442A preadipocytes yakakonzera kukurumidza kupatsanurwa kwesero uye kusiyanisa kwakasiyana, kunoonekwa kuburikidza nemorphologic zvidzidzo (chiedza, kuvheneka uye kutumira maelectron microscopy), metabolic analyzes. fatty acid profile uye lipolysis) uye adipogenic marker transcripts (Cebpα, Pparγ, aP2, ADRP, Perilipin).Munyika yose yeadipogenesis uye painopikiswa nemafuta, Bbs4 masero akanyarara anounganidza zvakanyanya triglycerides kupfuura kudzora adipocytes, kunyange mudiki (asi mukuru munhamba) madonhwe ane modified fatty acid profiles.Nokudaro, kuwanda kwemafuta akawanda mumasero akanyarara ndiwo mhedzisiro yehuwandu hwepamusoro hwekuwedzera kweadipocyte uye yekusiyanisa kusinganzwisisike kunotungamira kukuwedzera kuunganidzwa kwemafuta pasero.Zvatinowana zvinoratidza kuti kufutisa kweBBS kungangove kwakakonzeresa basa rakananga reBBS4 mune zvemuviri uye pathophysiological maitiro ayo ari pasi peadipose tissue kugadzirwa zvine chekuita nekufutisa.